Recently I've had two SD Cards failing on me in a very short period. One of them was acceptable, as it ran 24/7 for almost 4 years, but the other one only worked for one week.
Both failed so bad that no data at all is recoverable.
At this point I'm wondering whether it's better to just use a USB stick instead. Would that be more reliable?
Sometimes there are power shortages and the Pi looses power. I can't do anything about it, and a battery backup is not an option in my case.
As a power supply I use a modular PC ATX (Corsair RM750x). The PSU cable that powers the Pi is one with 3 Molex connectors, but i only use one of them with a Molex to Micro-USB adapter and the other ones are left unused (to avoid voltage issues).