After some searching, I haven't been able to diagnose whether this is a typical response or not.
After a fresh install of Jessie lite, Node.JS 5.5.0 from node's latest dist for arm and express, set up nginx for serving my static content and be my proxy for nginx. Nginx currently serves the favicon, any of the smaller images (will use photo hosting site eventually for larger images), stylesheets and scripts. I have node running with express to generate html from jade and jade-bootstrap mix-ins.
Right when visiting the site locally (haven't exposed my server yet), I get a 10 second waiting period before the server responds. I've also noticed it takes a few seconds for Node to start running when I do start the server. Is there any suggestions on how to fix this, or is this to be expected with node on the RPi?
Edit: Before I had nginx handle my static files, my response time was 25 seconds